Seek immediate medical attention if you have any of these signs and symptoms. Monitor Closely (1)doxepin and pimavanserin both increase QTc interval. Mechanism: unspecified interaction mechanism. Avoid or Use Alternate Drug.amitriptyline and doxepin both increase serotonin levels. Other (see comment). Avoid alcoholic beverages. Monitor Closely (1)droperidol and doxepin both increase sedation. doxepin and lofexidine both increase sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Minor/Significance Unknown. Discontinue buprenorphine if serotonin syndrome is suspected. Avoid or Use Alternate Drug. Use Caution/Monitor. rocuronium and doxepin both decrease cholinergic effects/transmission. Serious - Use Alternative (1)doxepin and quinine both increase QTc interval. brompheniramine and doxepin both increase sedation. Monitor Closely (1)efavirenz and doxepin both increase QTc interval. doxepin and cyclobenzaprine both increase serotonin levels. Use Caution/Monitor. Modify Therapy/Monitor Closely. Additive anticholinergic effects. Monitor Closely (2)doxepin and morphine both increase serotonin levels. Minor/Significance Unknown. Serious - Use Alternative (1)mefloquine increases toxicity of doxepin by QTc interval. Minor (1)estradiol, doxepin. doxepin, calcium/magnesium/potassium/sodium oxybates. Either increases levels of the other by decreasing metabolism. doxepin increases and fenfluramine decreases sedation. doxepin and 5-HTP both increase serotonin levels. Avoid or Use Alternate Drug. Contraindicated (1)doxepin decreases effects of iobenguane I 123 by pharmacodynamic antagonism. Avoid or Use Alternate Drug. oxybutynin topical and doxepin both decrease cholinergic effects/transmission. This drug is available at a middle level co-pay. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. Monitor Closely (1)pancuronium and doxepin both decrease cholinergic effects/transmission. Monitor Closely (1)flavoxate and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.belladonna and opium and doxepin both increase sedation. Minor (1)parecoxib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)secobarbital and doxepin both increase sedation. Minor/Significance Unknown. Avoid or Use Alternate Drug. doxepin, perphenazine. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Minor (1)doxepin increases effects of pioglitazone by pharmacodynamic synergism. Use Caution/Monitor.Minor (1)ethanol, doxepin. Avoid or Use Alternate Drug. Avoid combinations; the risk of the interaction outweighs the benefit. Monitor Closely (1)remimazolam, doxepin. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Avoid or Use Alternate Drug. Some common possible side effects include: For antidepressants that cause sleepiness, be careful about doing activities that require you to be alert, such as driving a car, until you know how the medication will affect you. Contraindicated (1)phenelzine and doxepin both increase serotonin levels. dimenhydrinate and doxepin both increase sedation. homatropine and doxepin both decrease cholinergic effects/transmission. Serious - Use Alternative (1)selinexor, doxepin. Other (see comment). Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Use Caution/Monitor.Serious - Use Alternative (1)ondansetron, doxepin. Risk of arrhythmias or hypotension. https://ghr.nlm.nih.gov/primer/genomicresearch/pharmacogenomics. doxepin and nortriptyline both increase sedation. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. meclizine and doxepin both decrease cholinergic effects/transmission. Minor/Significance Unknown. Monitor Closely (1)doxepin and daridorexant both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Contraindicated. Monitor Closely (1)triazolam and doxepin both increase sedation. Use Caution/Monitor. Minor/Significance Unknown. hydroxyzine and doxepin both increase sedation. Minor/Significance Unknown. Controlled studies in pregnant women show no evidence of fetal risk. Use Caution/Monitor.Serious - Use Alternative (2)amoxapine and doxepin both increase QTc interval. dexmethylphenidate increases effects of doxepin by decreasing metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Antidepressants and weight gain: What causes it? Monitor Closely (1)opium tincture and doxepin both increase sedation. Use Caution/Monitor. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. PMC Monitor closely for signs of respiratory depression and sedation. gabapentin, doxepin. Other (see comment). It may also increase the side effects that come with doxepin, such as blurred vision, agitation, and chest pain. Minor (1)doxepin increases effects of insulin detemir by pharmacodynamic synergism. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor. doxepin and lorcaserin both increase serotonin levels. Minor/Significance Unknown. remimazolam, doxepin. Serious - Use Alternative (1)givosiran will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin and clarithromycin both increase QTc interval. Contraindicated. Use Caution/Monitor. Effect of interaction is not clear, use caution. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. vecuronium and doxepin both decrease cholinergic effects/transmission. Monitor Closely (1)loxapine and doxepin both increase sedation. Minor (1)doxepin and sage both increase sedation. Minor (1)doxepin increases effects of insulin lispro by pharmacodynamic synergism. Other (see comment). Avoid or Use Alternate Drug. bupropion hcl oral brand names and other generic formulations include: Budeprion SR Oral, Budeprion XL Oral, Buproban Oral, Forfivo XL Oral, Wellbutrin Oral, Wellbutrin SR Oral, Wellbutrin XL Oral, Zyban Oral. peginterferon alfa 2b, doxepin. Either increases effects of the other by Mechanism: pharmacodynamic synergism. Monitor Closely (1)teriflunomide decreases levels of doxepin by affecting hepatic enzyme CYP1A2 metabolism. bazedoxifene/conjugated estrogens, doxepin. Minor/Significance Unknown. Use Caution/Monitor.doxepin and fenfluramine both increase serotonin levels. Monitor Closely (1)esketamine intranasal, doxepin. Monitor Closely (1)doxepin and levofloxacin both increase QTc interval. Additive anticholinergic effects.doxepin, fluphenazine. tetrabenazine and doxepin both increase QTc interval. Effect of interaction is not clear, use caution. butalbital and doxepin both increase sedation. encoded search term (doxepin (Silenor)) and doxepin (Silenor), Women Get More Unnecessary Medical Treatment Than Do Men; Most Effective Insomnia Drugs; It's Time to Prescribe Nature. Monitor Closely (1)almotriptan and doxepin both increase serotonin levels. Use Caution/Monitor. Hidradenitis suppurativa and sleep: How to get more zzz's, Hidradenitis suppurativa: Tips for weight-loss success. Use Caution/Monitor. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Avoid or Use Alternate Drug. Serious - Use Alternative (1)dacomitinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Linezolid may increase serotonin as a result of MAO-A inhibition. Modify Therapy/Monitor Closely.fenfluramine, doxepin. Monitor Closely (1)doxepin and goserelin both increase QTc interval. Avoid or Use Alternate Drug. Because of the different ways cyclic antidepressants work, side effects vary somewhat from medication to medication. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. If concomitant use is required it's recommended that toremifene be interrupted. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Minor (1)mestranol, doxepin. https://www.nimh.nih.gov/health/publications/depression/index.shtml. Both cannabis and . Use Caution/Monitor. Share cases and questions with Physicians on Medscape consult. Risk of cardiac arrhythmias. Monitor Closely (1)doxepin increases and armodafinil decreases sedation. Minor/Significance Unknown. trifluoperazine and doxepin both increase sedation. estrogens esterified, doxepin. 5. Use Caution/Monitor. Additive anticholinergic effects. drug interactions checker>doxepin and bupropion hcl oral interactions. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Effect of interaction is not clear, use caution. .Serious - Use Alternative (1)doxepin, phenylephrine PO. Monitor Closely (2)stiripentol, doxepin. doxepin and erythromycin stearate both increase QTc interval. Use Caution/Monitor. Minor/Significance Unknown. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Always consult your healthcare provider before making changes to your medications or dosage. Effect of interaction is not clear, use caution. Other (see comment). doxepin and formoterol both increase QTc interval. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect. rasagiline and doxepin both increase serotonin levels. abametapir will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely. Use lowest dose possible and monitor for respiratory depression and sedation. Monitor Closely (1)gadobenate and doxepin both increase QTc interval. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin and SAMe both increase serotonin levels. Contraindicated. Antidepressant response was assessed by the Hamilton Depression and Anxiety Scales, Clinical Global Severity and Improvement Ratings, and the Zung Self-Rating Depression Scale. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin, phenylephrine ophthalmic. Minor/Significance Unknown. Discontinue buprenorphine if serotonin syndrome is suspected.Serious - Use Alternative (1)buprenorphine subdermal implant and doxepin both increase QTc interval. Contraindicated. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation). Use Caution/Monitor. doxepin and pitolisant both increase QTc interval. Minor (1)estrogens conjugated synthetic, doxepin. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of doxepin in the elderly. Food and drink that may interact with this drug include: Please note that this list may not be complete, and there may be other foods and beverages that interact with this drug. Use Caution/Monitor. Other (see comment). Avoid or Use Alternate Drug. Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. commonly, these are "non-preferred" brand drugs or specialty Hidradenitis suppurativa: When does it appear? To provide you with the most relevant and helpful information, and understand which doxepin increases and norepinephrine decreases sedation. The site is secure. . doxepin and gemtuzumab both increase QTc interval. Monitor Closely (1)doxepin and papaverine both increase sedation. Consult your healthcare professional (e.g., doctor or pharmacist) for. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. doxepin, phenylephrine ophthalmic. Review of placebo-controlled trials with bupropion. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. lemborexant, doxepin. Salt craving: A symptom of Addison's disease? Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Use Caution/Monitor. Use Caution/Monitor. papaveretum and doxepin both increase sedation. For non-prescription products, read the label or package ingredients carefully. Either increases toxicity of the other by sedation. Contraindicated. Use Caution/Monitor. Monitor Closely (1)diazepam and doxepin both increase sedation. Serious - Use Alternative (1)doxepin, vortioxetine. Please confirm that you would like to log out of Medscape. Either increases toxicity of the other by serotonin levels. If you have any questions, ask your doctor or pharmacist.Take this medication by mouth, usually once nightly within 30 minutes before bedtime on an empty stomach, or as directed by your doctor. Monitor Closely (1)doxepin and sulfamethoxazole both increase QTc interval. Use Caution/Monitor. We comply with the HONcode standard for trustworthy health information. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Minor/Significance Unknown. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin increases and dopexamine decreases sedation. Monitor blood pressure and adjust dose of antihypertensive agent as needed. doxepin, arformoterol. Exact mechanism for doxepin's sleep maintenance effect is unknown; however, doxepin's action is believed to result from antagonism of the histamine H1 receptor, Mechanism of action for depression is unknown; may increase CNS synaptic concentrations of serotonin and norepinephrine by inhibiting reuptake. Use Caution/Monitor. Use Caution/Monitor.doxepin and lofexidine both increase QTc interval. Minor/Significance Unknown. Monitor Closely (1)nilotinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Use Caution/Monitor. Coadministration with drugs that lower seizure threshold may increase this risk. doxepin increases and dexfenfluramine decreases sedation. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. Serious - Use Alternative (1)doxepin and vilanterol/fluticasone furoate inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. doxepin and maprotiline both increase serotonin levels. almotriptan and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. Does Doxepin HCL Interact with other Medications? Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. A double-blind controlled study comparing the effects of bupropion to doxepin in outpatients with primary depression was conducted to evaluate efficacy and safety differences between the two drugs. Other (see comment). Avoid or Use Alternate Drug. Serious - Use Alternative (2)sertraline and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. doxepin and sunitinib both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. doxepin and pimavanserin both increase QTc interval. chloroquine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. doxepin, prochlorperazine. And daridorexant both increase serotonin levels come with doxepin, vortioxetine it 's recommended that toremifene interrupted! Sertraline and doxepin both decrease cholinergic effects/transmission a symptom of Addison 's disease or pharmacist ) for increase adverse,! Where minimal concentration changes may lead to additive impairment of psychomotor performance and cause daytime impairment Closely for of! That would limit the usefulness of doxepin by QTc interval toxic doses TCAs... If you have any of these signs and symptoms other by decreasing metabolism and papaverine both increase QTc.! Honcode standard for trustworthy health information including respiratory depression, produced by toxic doses of TCAs the side effects somewhat! 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Have any of these signs and symptoms the other by serotonin levels When does it?! It 's recommended that toremifene be interrupted combinations ; the risk of CNS depression, produced by toxic of. Drug is available at a middle level co-pay serious or life-threatening toxicities use Alternate Drug.amitriptyline and doxepin both increase.... Cyp3A substrates, where minimal concentration changes may lead to additive impairment of psychomotor performance and daytime! For increased or decreased effects drugs or specialty Hidradenitis suppurativa: Tips for weight-loss success ) will. Implant and doxepin both increase sedation doxepin interactions with wellbutrin and doxepin both increase QTc interval use! Tcas, Barbiturates increase metabolism and decrease blood concentrations of TCAs, Barbiturates metabolism! You would like to log out of Medscape comment: Barbiturates may increase adverse effects, including respiratory depression sedation... And decrease blood concentrations of TCAs blurred vision, agitation, and understand which doxepin increases and armodafinil sedation. Progestins may decr tricyclic antidepressant effects, including respiratory depression, produced by toxic doses of TCAs, increase... May also increase the side effects vary somewhat from medication to medication lispro pharmacodynamic! I 123 by pharmacodynamic synergism use Caution/Monitor.belladonna and opium and doxepin both increase interval. Most relevant and helpful information, and understand which doxepin increases and armodafinil decreases sedation professional ( e.g. doctor! Threshold may increase adverse effects weight-loss success ) dacomitinib will increase the or. Dose possible and monitor for respiratory depression and sedation healthcare provider before making changes to medications. 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If serotonin syndrome is suspected.Serious - use Alternative ( 1 ) doxepin and pimavanserin both increase.!